During a 6-year surveillance period — , we conducted a prospective, community-based study at an impoverished urban site in Kolkata. July 25, Page last reviewed: Am J Clin Pathol.


During the — surveillance period, we isolated V. The latter became the predominant serotype only in In , a sudden upsurge in tetracycline resistance was noted among V. Tetracycline is the drug of choice for treating cholera 1 ; however, during the 6-year period, we observed the emergence of tetracycline resistance among V.

Tetracycline resistance was also reported by Mhalu et al. In a similar situation, the extensive prophylactic use of tetracycline triggered the rapid emergence and spread of tetracycline-resistant strains in Madagascar 4. Tetracycline is not used for prophylaxis in Kolkata, a known cholera-endemic area. Nonetheless, the emergence of resistant strains in our study area is not surprising because similar tetracycline-resistant strains of V.

In our study, resistance to tetracycline among V. The reasons for the sudden rise of resistant strains in and their continued persistence are still unclear. Detailed molecular studies are underway to find the explanation. Alternative drugs, such as the newer fluoroquinolones, possess excellent activity against V.

However, increased resistance to newer fluoroquinolones, such as ciprofloxacin and norfloxacin, among V. Resistance to commonly used antimicrobial drugs represents a critical public health problem because it complicates treatment and may result in longer hospital stays for patients. In addition, most of the population in developing countries cannot afford the newer and more expensive drugs. Our findings emphasize the need for continued surveillance of antimicrobial drug susceptibility patterns of V.

Providing early information on antimicrobial drug susceptibility to practitioners in affected areas will lessen the illness and death from this devastating disease. Table of Contents — Volume 17, Number 3—March Please use the form below to submit correspondence to the authors or contact them at the following address:. The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.

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